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sdf1 α  (R&D Systems)


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    R&D Systems sdf1 α
    Sdf1 α, supplied by R&D Systems, used in various techniques. Bioz Stars score: 95/100, based on 223 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/sdf1 α/product/R&D Systems
    Average 95 stars, based on 223 article reviews
    sdf1 α - by Bioz Stars, 2026-03
    95/100 stars

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    Design of nanoengineered dual cross-linked DNA-based hydrogels for in situ tissue repair. The amine groups present in the DNA nucleotides can react with the epoxide functionalities of the cross-linker polyethylene glycol diglycidyl ether (PEGDE) to form a chemically conjugated DNA network. Silicate nanodisks (nSi) act as physical cross-linkers which provides additional bridging points by establishing electrostatic interactions between their positively charged edges and the negatively charged phosphate groups of the DNA. Under compression, these additional network points enable the material to resist deformation, resulting in pronounced elastomeric properties with minimum permanent deformation. The nanoengineered hydrogels with encapsulated stromal cell-derived factor-1 alpha (SDF-1α) can function as stem cell recruiting materials for tissue repair applications.

    Journal: ACS applied materials & interfaces

    Article Title: Nucleic Acid-Based Dual Cross-Linked Hydrogels for in Situ Tissue Repair via Directional Stem Cell Migration

    doi: 10.1021/acsami.9b10074

    Figure Lengend Snippet: Design of nanoengineered dual cross-linked DNA-based hydrogels for in situ tissue repair. The amine groups present in the DNA nucleotides can react with the epoxide functionalities of the cross-linker polyethylene glycol diglycidyl ether (PEGDE) to form a chemically conjugated DNA network. Silicate nanodisks (nSi) act as physical cross-linkers which provides additional bridging points by establishing electrostatic interactions between their positively charged edges and the negatively charged phosphate groups of the DNA. Under compression, these additional network points enable the material to resist deformation, resulting in pronounced elastomeric properties with minimum permanent deformation. The nanoengineered hydrogels with encapsulated stromal cell-derived factor-1 alpha (SDF-1α) can function as stem cell recruiting materials for tissue repair applications.

    Article Snippet: The concentration of released SDF-1 α in the PBS was quantified using a human SDF-1 α ELISA Assay Kit (R&D systems–DSA00) following the manufacturer’s protocol.

    Techniques: In Situ, Derivative Assay